Aqualung Publications
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View relevant publications demonstrating the efficacy of ALT-100 mAb in preclinical models
ALT-100 mAb
Phase 1A Trial, ALT-100 mAb
PUERTA ARDS Phase 2 Trial, ALT-100 mAb
ARDS/Sepsis, ALT-100 mAb
Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody
Published 2022
eNAMPT neutralization reduces preclinical ARDS severity via rectifed NFkB and Akt/mTORC2signaling
Published 2022
eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury
Published 2022
Pulmonary Fibrosis, ALT-100 mAb
Hepatic Fibrosis, ALT-100 mAb
Cancer, ALT-100 mAb
eNAMPT Is a Novel DAMP and Therapeutic Target in Human and Murine Pulmonary Fibrosis
Published 2025
eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis
Published March 2022
Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization
Published June 2021
Preterm Births/Chorio, ALT-100 mAb
Lupus Vasculitis, ALT-100 mAb
The eNAMPT/TLR4 inflammatory cascade drives the severity of intra-amniotic inflammation in pregnancy and predicts infant outcomes
Published 2023
Extracellular Nicotinamide Phosphoribosyltransferase Is aTherapeutic Target in Experimental Necrotizing Enterocolitis
Published 2024
An eNAMPT-neutralizing mAb attenuates the fetal inflammatory response syndrome (FIRS) in a preclinical pregnant sheep model
Published 2025
Pulmonary Hypertension- ALT-100 mAb
Cardiac Fibrosis / Vascular Disease, ALT-100 mAb
Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling
Published 2020
Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and is a Therapeutic Target in Pulmonary Arterial Hypertension
Published 2017
Endothelial eNAMPT drives EndMT and preclinical PH:rescue by an eNAMPT-neutralizing mAb
Published 2021
eNAMPT/TLR4 signaling drives PAH cellular phenotypic switching and lung vascular remodeling
Published 2025
Role of secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in prostate cancer progression: Novel biomarker and therapeutic target
Published 2020
A Humanized Monoclonal Antibody Targeting Extracellular Nicotinamide Phosphoribosyltransferase Prevents Aggressive Prostate Cancer Progression
Published 2021
Extracellular nicotinamidephosphoribosyltransferase (eNAMPT)neutralization counteracts T cell immune evasion in breast cancer
Published 2023
Trauma Induced Lung Injury, ALT-100 mAb
Radiation Induced Lung Injury, ALT-100 mAb
NTyP-100 Nanocarrier
ARDS/Sepsis, NTyP-100 Nanocarrier
Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury
Published 2004
Mechanisms of sodium fluoride-induced endothelial cell barrier dysfunction: role of MLC phosphorylation
Published 2022
Critical role for the lung endothelial nonmuscle myosin light-chain kinase isoform in the severity of inflammatory murine lung injury
Published 2022