Pulmonary Hypertension

❖ Pulmonary Arterial Hypertension (Idiopathic, Secondary, Autoimmune)

❖ ~100,000 patients in US/year

❖ 70% women with PAH

Median PAH survival 3 years

US PAH market size $5.3B annually

❖ PAH growing at a rate of ~4.9% per year

❖ Market Opportunity

Current FDA-Approved Therapies for PAH

❖Therapies exist that improve QOL and slow progression

❖Curative therapies do not exist

❖No therapies exist that halt progression

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